PCWG
RESEARCH

Recent Prostate Cancer Working Group Member Papers

Updated quarterly – last update December 2012

◊ indicates a PCWG collaborative effort

December

◊ NCI-RTOG Translational Program Strategic Guidelines for the Early-Stage Development of Radiosensitizers. Lawrence YR, Vikram B, Dignam JJ, Chakravarti A, Machtay M, Freidlin B, Takebe N, Curran WJ Jr, Bentzen SM, Okunieff P, Coleman CN, Dicker AP. J Natl Cancer Inst. 2012 Dec 10. [Epub ahead of print] PubMed

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP. Nat Chem Biol. 2012 Dec 9. doi: 10.1038/nchembio.1140. [Epub ahead of print] PubMed

COX-2 Expression and Survival in Patients With Locally Advanced Cervical Cancer Treated With Chemoradiotherapy and Celecoxib: A Quantitative Immunohistochemical Analysis of RTOG C0128. Doll CM, Winter K, Gaffney DK, Ryu JK, Jhingran A, Dicker AP, Weidhaas JB, Miller BE, Magliocco AM. Int J Gynecol Cancer. 2012 Dec 7. [Epub ahead of print] PubMed

On the Merits and Limitations of Whole-Brain Radiation Therapy. Khan AJ, Dicker AP. J Clin Oncol. 2012 Dec 3. [Epub ahead of print] PubMed

Stereotactic body radiation therapy for prostate cancer: Is the technology ready to be the standard of care? Zaorsky NG, Studenski MT, Dicker AP, Gomella L, Den RB. Cancer Treat Rev. 2012 Dec 3. doi:pii: S0305-7372(12)00210-1. 10.1016/j.ctrv.2012.10.003. [Epub ahead of print] PubMed

A patient alignment solution for lung SBRT setups based on a deformable registration technique. Lu B, Mittauer K, Li J, Samant S, Dagan R, Okunieff P, Kahler D, Liu C. Med Phys. 2012 Dec;39(12):7379-89. doi: 10.1118/1.4766875. PubMed

BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: Implications for breast cancer prevention with antioxidant therapies. Martinez-Outschoorn UE, Balliet R, Lin Z, Whitaker-Menezes D, Birbe RC, Bombonati A, Pavlides S, Lamb R, Sneddon S, Howell A, Sotgia F, Lisanti MP. Cell Cycle. 2012 Dec 1;11(23):4402-13. doi: 10.4161/cc.22776. Epub 2012 Nov 21. PubMed

Circumcision: a spiritual, medical or criminal act? Gomella LG. Can J Urol. 2012 Dec;19(6):6530. PubMed

◊ Predictors of Radiation Oncology Resident Research Productivity. Gutovich JM, Den RB, Werner-Wasik M, Dicker AP, Lawrence YR. J Am Coll Radiol. 2012 Dec 13. doi:pii: S1546-1440(12)00386-9. 10.1016/j.jacr.2012.06.036. [Epub ahead of print] PubMed

Radiation Therapy Use and Outcomes Among Older Women With ER-Positive and ER-Negative Stage I Breast Cancer. Shen X, Anne PR, Keith SW, Wojcieszynski A, Mishra MV, Bar-Ad V, Showalter TN. Am J Clin Oncol. 2012 Dec 13. [Epub ahead of print] PubMed

November

◊ Novel Oncogene Induced Metastatic Prostate Cancer Cell Lines Define Human Prostate Cancer Progression Signatures. Ju X, Ertel A, Casimiro M, Yu Z, Meng H, McCue PA, Walters R, Fortina P, Lisanti MP, Pestell RG. Cancer Res. 2012 Nov 30. [Epub ahead of print] PubMed

Predictors of patient uptake of colorectal cancer gene environment risk assessment. Hall MJ, Manne SL, Myers RE, Keenan EM, Balshem AM, Weinberg DS. Genome Med. 2012 Nov 29;4(11):92. [Epub ahead of print] PubMed

RTOG 0211: A Phase 1/2 Study of Radiation Therapy With Concurrent Gefitinib for Newly Diagnosed Glioblastoma Patients. Chakravarti A, Wang M, Robins HI, Lautenschlaeger T, Curran WJ, Brachman DG, Schultz CJ, Choucair A, Dolled-Filhart M, Christiansen J, Gustavson M, Molinaro A, Mischel P, Dicker AP, Bredel M, Mehta M. Int J Radiat Oncol Biol Phys. 2012 Nov 22. doi:pii: S0360-3016(12)03658-9. 10.1016/j.ijrobp.2012.10.008. [Epub ahead of print] PubMed

Synthesis and photophysical properties of phosphorus(v) porphyrins functionalized with axial carbazolylvinylnaphthalimides. Zhan Y, Cao K, Wang C, Jia J, Xue P, Liu X, Duan X, Lu R. Org Biomol Chem. 2012 Nov 21;10(43):8701-9. doi: 10.1039/c2ob26478a. PubMed

Hyaluronan (HA) Interacting Proteins RHAMM and Hyaluronidase Impact Prostate Cancer Cell Behavior and Invadopodia Formation in 3D HA-Based Hydrogels. Gurski LA, Xu X, Labrada LN, Nguyen NT, Xiao L, van Golen KL, Jia X, Farach-Carson MC. PLoS One. 2012;7(11):e50075. doi: 10.1371/journal.pone.0050075. Epub 2012 Nov 16. PubMed

The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones. Zhang L, Jin Y, Huang M, Penning TM. Front Pharmacol. 2012;3:193. doi: 10.3389/fphar.2012.00193. Epub 2012 Nov 16. PubMed

Knockdown of ki-67 by dicer-substrate small interfering RNA sensitizes bladder cancer cells to curcumin-induced tumor inhibition. Pichu S, Krishnamoorthy S, Shishkov A, Zhang B, McCue P, Ponnappa BC. PLoS One. 2012;7(11):e48567. doi: 10.1371/journal.pone.0048567. Epub 2012 Nov 12. PubMed

Modeling and characterization of inflammatory breast cancer emboli grown in vitro. Lehman HL, Dashner EJ, Lucey M, Vermeulen P, Dirix L, Van Laere S, van Golen KL. Int J Cancer. 2012 Nov 6. doi: 10.1002/ijc.27928. [Epub ahead of print] PubMed

A Randomized Controlled Trial of Tailored Navigation and Standard Intervention in Colorectal Cancer Screening. Myers RE, Fagan HB, Daskalakis C, Sifri R, Vernon SW, Cocroft J, Dicarlo M, Katurakes NC, Andrel J. Cancer Epidemiol Biomarkers Prev. 2012 Nov 1. [Epub ahead of print] PubMed

◊ Contrast enhanced transrectal ultrasound for the detection of prostate cancer: a randomized, double-blind trial of dutasteride pretreatment. Halpern EJ, Gomella LG, Forsberg F, McCue PA, Trabulsi EJ. J Urol. 2012 Nov;188(5):1739-45. doi: 10.1016/j.juro.2012.07.021. PubMed

Diagnostic accuracy of transrectal elastosonography (TRES) imaging for the diagnosis of prostate cancer: a systematic review and meta-analysis. Gomella LG. BJU Int. 2012 Nov;110(10):1423. doi: 10.1111/j.1464-410X.2012.11131.x. PubMed

Molecular-based and alternative therapies for pancreatic cancer: looking "out of the box". Tholey R, Sawicki JA, Brody JR. Cancer J. 2012 Nov;18(6):665-73. doi: 10.1097/PPO.0b013e3182793ff6. PubMed

Diagnostic Performance of PCA3 to Detect Prostate Cancer in Men with Increased Prostate Specific Antigen: A Prospective Study of 1,962 Cases. Crawford ED, Rove KO, Trabulsi EJ, Qian J, Drewnowska KP, Kaminetsky JC, Huisman TK, Bilowus ML, Freedman SJ, Glover WL Jr, Bostwick DG. J Urol. 2012 Nov;188(5):1726-31. doi: 10.1016/j.juro.2012.07.023. PubMed

◊ Targeting angiogenesis as a promising modality for the treatment of prostate cancer. Lin J, Kelly WK. Urol Clin North Am. 2012 Nov;39(4):547-60. doi: 10.1016/j.ucl.2012.07.010. PubMed

Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β(1) integrin-RACK1 axis. Trerotola M, Li J, Alberti S, Languino LR. J Cell Physiol. 2012 Nov;227(11):3670-7. doi: 10.1002/jcp.24074. PubMed

Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver-Update 2012: A WFUMB-EFSUMB Initiative in Cooperation With Representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Claudon M, Dietrich CF, Choi BI, Cosgrove DO, Kudo M, Nolsøe CP, Piscaglia F, Wilson SR, Barr RG, Chammas MC, Chaubal NG, Chen MH, Clevert DA, Correas JM, Ding H, Forsberg F, Fowlkes JB, Gibson RN, Goldberg BB, Lassau N, Leen EL, Mattrey RF, Moriyasu F, Solbíatí L, Weskott HP, Xu HX. Ultrasound Med Biol. 2012 Oct 30. doi:pii: S0301-5629(12)00543-1. 10.1016/j.ultrasmedbio.2012.09.002. [Epub ahead of print] PubMed

October

Mitochondrial HSP90s and tumor cell metabolism. Altieri DC Autophagy. 2012 Oct 29;9(2). PubMed

Cyclin D1 goes metabolic: Dual functions of cyclin D1 in regulating lipogenesis. Knudsen KE. Cell Cycle. 2012 Oct 1;11(19):3534. doi: 10.4161/cc.22039. PubMed

Activation of Nuclear Factor κB (NF-κB) in Prostate Cancer Is Mediated by Protein Kinase C Ε (PKCΕ). Garg R, Blando J, Perez CJ, Wang H, Benavides FJ, Kazanietz MG. J Biol Chem. 2012 Oct 26;287(44):37570-82. doi: 10.1074/jbc.M112.398925. PubMed

Targeted Therapy for Metastatic Colorectal Cancer: Role of Aflibercept. Mitchell EP. Clin Colorectal Cancer. 2012 Oct 24. doi:pii: S1533-0028(12)00106-5. 10.1016/j.clcc.2012.08.001. PubMed

◊ DNA Nanotherapy for Pre-neoplastic Cervical Lesions. Peng W, Dunton C, Holtz D, Parva M, Stampler K, Forwood M, Gogoi R, Lace MJ, Anderson DG, Sawicki JA. Gynecol Oncol. 2012 Oct 23. doi:pii: S0090-8258(12)00844-X. 10.1016/j.ygyno.2012.10.018. PubMed

Diagnosis of Inguinal Lymph Node Metastases Using Contrast Enhanced High Resolution MR Lymphangiography. Liu N, Yan Z, Lu Q, Wang C. Acad Radiol. 2012 Oct 22. doi:pii: S1076-6332(12)00487-4. 10.1016/j.acra.2012.09.014. PubMed

Efficiency of study designs in diagnostic randomized clinical trials. Lu B, Gatsonis C. Stat Med. 2012 Oct 15. doi: 10.1002/sim.5655. PubMed

◊ A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. Xu Q, Jiang Y, Yin Y, Li Q, He J, Jing Y, Qi YT, Xu Q, Li W, Lu B, Peiper SS, Jiang BH, Liu LZ. J Mol Cell Biol. 2012 Oct 10. PubMed

Using Qualitative Measures to Improve Quality in Radiation Oncology. Harrison AS, Yu Y, Dicker AP, Doyle LA. Am J Med Qual. 2012 Oct 6. PubMed

Attacking the flank: targeting new pathways in SBMA. Merry DE. Nat Med. 2012 Oct 5;18(10):1461-3. doi: 10.1038/nm.2967. PubMed

◊ Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes. Peck AR, Witkiewicz AK, Liu C, Klimowicz AC, Stringer GA, Pequignot E, Freydin B, Yang N, Ertel A, Tran TH, Girondo MA, Rosenberg AL, Hooke JA, Kovatich AJ, Shriver CD, Rimm DL, Magliocco AM, Hyslop T, Rui H. Breast Cancer Res. 2012 Oct 4;14(5):R130. PubMed

Radiation therapy for locally recurrent breast cancer. Siglin J, Champ CE, Vakhnenko Y, Anne PR, Simone NL. Int J Breast Cancer. 2012;2012:571946. doi: 10.1155/2012/571946. PubMed

Rho GEFs and Cancer: Linking Gene Expression and Metastatic Dissemination. Barrio-Real L, Kazanietz MG. Sci Signal. 2012 Oct 2;5(244):pe43. doi: 10.1126/scisignal.2003543. PubMed

◊ Biomarkers of aging and radiation therapy tailored to the elderly: future of the field. Mishra MV, Showalter TN, Dicker AP. Semin Radiat Oncol. 2012 Oct;22(4):334-8. doi: 10.1016/j.semradonc.2012.05.010. PubMed

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Capparelli C, Chiavarina B, Whitaker-Menezes D, Pestell TG, Pestell RG, Hulit J, Andò S, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Cell Cycle. 2012 Oct 1;11(19):3599-610. doi: 10.4161/cc.21884. PubMed

Glutamine depletion and glucose depletion trigger growth inhibition via distinctive gene expression reprogramming. Qie S, Liang D, Yin C, Gu W, Meng M, Wang C, Sang N. Cell Cycle. 2012 Oct 1;11(19):3679-90. doi: 10.4161/cc.21944. PubMed

Investigating the efficacy of subharmonic aided pressure estimation for portal vein pressures and portal hypertension monitoring. Dave JK, Halldorsdottir VG, Eisenbrey JR, Merton DA, Liu JB, Zhou JH, Wang HK, Park S, Dianis S, Chalek CL, Lin F, Thomenius KE, Brown DB, Forsberg F. Ultrasound Med Biol. 2012 Oct;38(10):1784-98. PubMed

Ligand effect on the catalytic activity of ruthenium nanoparticles in ionic liquids. Salas G, Campbell PS, Santini CC, Philippot K, Costa Gomes MF, Pádua AA. Dalton Trans. 2012 Oct 1. PubMed

Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer. Mills J, Oliver A, Sherwin JC, Frydenberg M, Peters JS, Costello A, Harewood L, Love C, Redgrave N, van Golen KL, Bailey M, Pedersen J. Pathology. 2012 Oct;44(6):513-518.`10/1/12 PubMed

September

Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis. Altieri DC. Cell Mol Life Sci. 2012 Sep 30. PubMed

Nuclear Stat5a/b predicts early recurrence and prostate cancer-specific death in patients treated by radical prostatectomy. Mirtti T, Leiby BE, Abdulghani J, Aaltonen E, Pavela M, Mamtani A, Alanen K, Egevad L, Granfors T, Josefsson A, Stattin P, Bergh A, Nevalainen MT. Hum Pathol. 2012 Sep 28. doi:pii: S0046-8177(12)00207-9. 10.1016/j.humpath.2012.06.001. PubMed

The association of red blood cell n-3 and n-6 fatty acids to dietary fatty acid intake, bone mineral density and hip fracture risk in the Women's Health Initiative. Orchard TS, Ing SW, Lu B, Belury MA, Johnson K, Wactawski-Wende J, Jackson RD. J Bone Miner Res. 2012 Sep 27. doi: 10.1002/jbmr.1772. PubMed

Uptake, efflux, and mass transfer coefficient of fluorescent PAMAM dendrimers into pancreatic cancer cells. Opitz AW, Czymmek KJ, Wickstrom E, Wagner NJ. Biochim Biophys Acta. 2012 Sep 26. doi:pii: S0005-2736(12)00337-9. 10.1016/j.bbamem.2012.09.016. PubMed

miRNAs regulate stem cell self-renewal and differentiation. Yu Z, Li Y, Fan H, Liu Z, Pestell RG. Front Genet. 2012;3:191. doi: 10.3389/fgene.2012.00191. PubMed

Weight gain, metabolic syndrome, and breast cancer recurrence: are dietary recommendations supported by the data? Champ CE, Volek JS, Siglin J, Jin L, Simone NL. Int J Breast Cancer. 2012;2012:506868. doi: 10.1155/2012/506868. PubMed

◊ Dual roles of PARP-1 promote cancer growth and progression. Schiewer MJ, Goodwin JF, Han S, Brenner JC, Augello MA, Dean JL, Liu F, Planck JL, Ravindranathan P, Chinnaiyan AM, McCue P, Gomella LG, Raj GV, Dicker AP, Brody JR, Pascal JM, Centenera MM, Butler LM, Tilley WD, Feng FY, Knudsen KE. Cancer Discov. 2012 Sep 19. PubMed

N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3. Sinreih M, Sosič I, Beranič N, Turk S, Adeniji AO, Penning TM, Rižner TL, Gobec S. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5948-51. PubMed

◊ Control of Tumor Bioenergetics and Survival Stress Signaling by Mitochondrial HSP90s. Chae YC, Caino MC, Lisanti S, Ghosh JC, Dohi T, Danial NN, Villanueva J, Ferrero S, Vaira V, Santambrogio L, Bosari S, Languino LR, Herlyn M, Altieri DC. Cancer Cell. 2012 Sep 11;22(3):331-44. PubMed

Comparison of different normalization assumptions for analyses of DNA methylation data from the cancer genome. Wang D, Zhang Y, Huang Y, Li P, Wang M, Wu R, Cheng L, Zhang W, Zhang Y, Li B, Wang C, Guo Z. Gene. 2012 Sep 10;506(1):36-42. PubMed

◊ Salvage radiotherapy for prostate cancer: Finding a way forward using radiobiological modeling. Ohri N, Shen X, Den RB, Dicker AP, Trabulsi EJ, Showalter TN. Cancer Biol Ther. 2012 Sep 6;13(14). PubMed

◊ Cancer stem cells. Yu Z, Pestell TG, Lisanti MP, Pestell RG. Int J Biochem Cell Biol. 2012 Sep 2;44(12):2144-2151. doi: 10.1016/j.biocel.2012.08.022. PubMed

◊ In Regard to Yeoh et al. Ohri N, Den R, Showalter TN. Int J Radiat Oncol Biol Phys. 2012 Sep 1;84(1):4. PubMed

Dynamic regulation of mitochondrial transcription as a mechanism of cellular adaptation. Blomain ES, McMahon SB. Biochim Biophys Acta. 2012 Sep;1819(9-10):1075-9. PubMed

◊ Metabolic reprogramming and two-compartment tumor metabolism: Opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells. Chiavarina B, Martinez-Outschoorn UE, Whitaker-Menezes D, Howell A, Tanowitz HB, Pestell RG, Sotgia F, Lisanti MP. Cell Cycle. 2012 Sep 1;11(17). PubMed

Reirradiation of recurrent meningioma. Wojcieszynski AP, Ohri N, Andrews DW, Evans JJ, Dicker AP, Werner-Wasik M. J Clin Neurosci. 2012 Sep;19(9):1261-4. PubMed

August

◊ CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling"" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Capparelli C, Chiavarina B, Whitaker-Menezes D, Pestell TG, Pestell RG, Andò S, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Cell Cycle. 2012 Aug 30;11(19).PubMed

Glutamine depletion and glucose depletion trigger growth inhibition via distinctive gene expression reprogramming. Qie S, Liang D, Yin C, Gu W, Meng M, Wang C, Sang N. Cell Cycle. 2012 Aug 30;11(19).PubMed

A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. Xu Q, Jiang Y, Yin Y, Li Q, He J, Jing Y, Qi YT, Xu Q, Li W, Lu B, Peiper SS, Jiang BH, Liu LZ. J Mol Cell Biol. 2012 Aug 29.PubMed

Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer. Mills J, Oliver A, Sherwin JC, Frydenberg M, Peters JS, Costello A, Harewood L, Love C, Redgrave N, van Golen KL, Bailey M, Pedersen J. Pathology. 2012 Aug 29.PubMed

CCN5 Expression in mammals. III. Early embryonic mouse development. Myers RB, Rwayitare K, Richey L, Lem J, Castellot JJ Jr. J Cell Commun Signal. 2012 Aug 28.PubMed

Selective Inhibitors of Aldo-Keto Reductases AKR1C1 and AKR1C3 Discovered by Virtual Screening of a Fragment Library. Brožič P, Turk S, Adeniji AO, Konc J, Janežič D, Penning TM, Lanišnik Ričner T, Gobec S. J Med Chem. 2012 Aug 27.PubMed

◊ Metabolic remodeling of the tumor microenvironment: Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth. Carito V, Bonuccelli G, Martinez-Outschoorn UE, Whitaker-Menezes D, Caroleo MC, Cione E, Howell A, Pestell RG, Lisanti MP, Sotgia F. Cell Cycle. 2012 Aug 23;11(18).PubMed

Investigating the Efficacy of Subharmonic Aided Pressure Estimation for Portal Vein Pressures and Portal Hypertension Monitoring. Dave JK, Halldorsdottir VG, Eisenbrey JR, Merton DA, Liu JB, Zhou JH, Wang HK, Park S, Dianis S, Chalek CL, Lin F, Thomenius KE, Brown DB, Forsberg F. Ultrasound Med Biol. 2012 Aug 21.PubMed

The association of anxiety and depression with future dementia diagnosis: a case-control study in primary care. Burton C, Campbell P, Jordan K, Strauss V, Mallen C. Fam Pract. 2012 Aug 21.PubMed

Medical Expenditures Associated with Nonfatal Occupational Injuries among Immigrant and U.S.-born Workers. Xiang H, Shi J, Lu B, Wheeler K, Zhao W, Wilkins JR 3rd, Smith GA. BMC Public Health. 2012 Aug 20;12(1):678.PubMed

Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Kim FJ, Schrock JM, Spino CM, Marino JC, Pasternak GW. Biochem Biophys Res Commun. 2012 Aug 17.PubMed

◊ A bioactive probe of the oxidative pentose phosphate cycle: Novel strategy to reverse radioresistance in glucose deprived human colon cancer cells. Li J, Ward KM, Zhang D, Dayanandam E, Denittis AS, Prendergast GC, Ayene IS. Toxicol In Vitro. 2012 Aug 16.PubMed

Enhanced gene transfection using calcium phosphate co-precipitates and low-intensity pulsed ultrasound. Hassan MA, Ahmed IS, Campbell P, Kondo T. Eur J Pharm Sci. 2012 Aug 16.PubMed

◊ Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production. Guido C, Whitaker-Menezes D, Capparelli C, Balliet R, Lin Z, Pestell RG, Howell A, Aquila S, Andò S, Martinez-Outschoorn U, Sotgia F, Lisanti MP. Cell Cycle. 2012 Aug 15;11(16):3019-35.PubMed

Regulation of inflammatory breast cancer cell invasion through Akt1/PKBα phosphorylation of RhoC GTPase. Lehman HL, Van Laere SJ, van Golen CM, Vermeulen PB, Dirix LY, van Golen KL. Mol Cancer Res. 2012 Aug 15.PubMed

◊ Patterns of Care for Elderly Men Diagnosed With Favorable-risk Prostate Cancer From 2004 to 2008: A Population-based Analysis. Mishra MV, Shen X, Den RB, Champ CE, Trabulsi EJ, Lallas CD, Gomella LG, Dicker AP, Showalter TN. Am J Clin Oncol. 2012 Aug 13.PubMed

p53 Mutagenesis by Benzo[a]pyrene Derived Radical Cations. Sen S, Bhojnagarwala P, Francey L, Lu D, Penning TM, Field J. Chem Res Toxicol. 2012 Aug 9.PubMed

The influence of employment social support for risk and prognosis in nonspecific back pain: a systematic review and critical synthesis. Campbell P, Wynne-Jones G, Muller S, Dunn KM. Int Arch Occup Environ Health. 2012 Aug 9.PubMed

◊ Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth. Guido C, Whitaker-Menezes D, Lin Z, Pestell RG, Howell A, Zimmers TA, Casimiro MC, Aquila S, Ando' S, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Oncotarget. 2012 Aug 7.PubMed

A longitudinal study of major and minor depression following traumatic brain injury. Hart T, Hoffman JM, Pretz C, Kennedy R, Clark AN, Brenner LA. Arch Phys Med Rehabil. 2012 Aug;93(8):1343-9.PubMed

Association of sleep and co-occurring psychological conditions at 1 year after traumatic brain injury. Fogelberg DJ, Hoffman JM, Dikmen S, Temkin NR, Bell KR. Arch Phys Med Rehabil. 2012 Aug;93(8):1313-8.PubMed

Benefits of exercise maintenance after traumatic brain injury. Wise EK, Hoffman JM, Powell JM, Bombardier CH, Bell KR. Arch Phys Med Rehabil. 2012 Aug;93(8):1319-23.PubMed

◊ CCR5 Antagonist Blocks Metastasis of Basal Breast Cancer Cells. Velasco-Velázquez M, Jiao X, De La Fuente M, Pestell TG, Ertel A, Lisanti MP, Pestell RG. Cancer Res. 2012 Aug 1;72(15):3839-50.PubMed

Change in inpatient rehabilitation admissions for individuals with traumatic brain injury after implementation of the medicare inpatient rehabilitation facility prospective payment system.Hoffman JM, Donoso Brown E, Chan L, Dikmen S, Temkin N, Bell KR. Arch Phys Med Rehabil. 2012 Aug;93(8):1305-12.PubMed

Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Guido C, Panza S, Santoro M, Avena P, Panno ML, Perrotta I, Giordano F, Casaburi I, Catalano S, De Amicis F, Sotgia F, Lisanti MP, Andò S, Aquila S. Cell Cycle. 2012 Aug 1;11(15):2911-21. Epub 2012 Aug 1.PubMed

Heath care reform: the carrot, the stick and the hippocratic oath. Gomella LG. Can J Urol. 2012 Aug;19(4):6324.PubMed

◊ HuR's post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells. Pineda DM, Rittenhouse DW, Valley CC, Cozzitorto JA, Burkhart RA, Leiby B, Winter JM, Weber MC, Londin ER, Rigoutsos I, Yeo CJ, Gorospe M, Witkiewicz AK, Sachs JN, Brody JR. Cancer Biol Ther. 2012 Aug 1;13(10):946-55.PubMed

Late toxicity rates following definitive radiotherapy for prostate cancer. Ohri N, Dicker AP, Showalter TN. Can J Urol. 2012 Aug;19(4):6373-80.PubMed

◊ Prognostic Factors and Outcomes After Definitive Treatment of Female Urethral Cancer: A Population-based Analysis. Champ CE, Hegarty SE, Shen X, Mishra MV, Dicker AP, Trabulsi EJ, Lallas CD, Gomella LG, Hyslop T, Showalter TN. Urology. 2012 Aug;80(2):374-82.PubMed

Reply. Champ CE, Showalter TN. Urology. 2012 Aug;80(2):381-2.PubMed

July

Characterization and Normal Measurements of the Left Ventricular Outflow Tract by ECG-gated Cardiac CT: Implications for Disorders of the Outflow Tract and Aortic Valve.Halpern EJ, Gupta S, Halpern DJ, Wiener DH, Owen AN. Acad Radiol. 2012 Jul 31.PubMed

Mitochondrial Heat Shock Protein-90 Modulates Vascular Smooth Muscle Cell Survival and the Vascular Injury Response in Vivo.Hoel AW, Yu P, Nguyen KP, Sui X, Plescia J, Altieri DC, Conte MS. Am J Pathol. 2012 Jul 27.PubMed

Impaired IFN-a production by Plasmacytoid dendritic cells favors regulatory T cell expansion and contributes to breast cancer progression. Sisirak V, Faget J, Gobert M, Goutagny N, Vey N, Treilleux I, Renaudineau S, Poyet G, Labidi-Galy SI, Goddard-Leon S, Durand I, Le Mercier I, Bajard A, Bachelot T, Puisieux A, Puisieux I, Blay JY, Menetrier-Caux C, Caux C, Bendriss-Vermare N. Cancer Res. 2012 Jul 25.PubMed

◊ Higher Levels of c-Met Expression and Phosphorylation Identify Cell Lines With Increased Sensitivity to AMG-458, a Novel Selective c-Met Inhibitor With Radiosensitizing Effects. Li B, Torossian A, Sun Y, Du R, Dicker AP, Lu B. Int J Radiat Oncol Biol Phys. 2012 Jul 24.PubMed

Liver grafts from CD39-overexpressing mice are protected from ischemia reperfusion injury due to reduced numbers of resident CD4(+) T cells. Pommey S, Lu B, McRae J, Stagg J, Hill P, Salvaris E, Robson SC, d'Apice AJ, Cowan PJ, Dwyer KM. Hepatology. 2012 Jul 24.doi: 10.1002/hep.25985.PubMed

◊ Assessing the value of an optional radiation oncology clinical rotation during the core clerkships in medical school. Zaorsky NG, Malatesta TM, Den RB, Wuthrick E, Ahn PH, Werner-Wasik M, Shi W, Dicker AP, Anne PR, Bar-Ad V, Showalter TN. Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):e465-9.PubMed

◊ Molecular profiling to optimize treatment in non-small cell lung cancer: a review of potential molecular targets for radiation therapy by the translational research program of the radiation therapy oncology group. Ausborn NL, Le QT, Bradley JD, Choy H, Dicker AP, Saha D, Simko J, Story MD, Torossian A, Lu B. Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):e453-64.PubMed

Phase I Trial Using the Proteasome Inhibitor Bortezomib and Concurrent Chemoradiotherapy for Head-and-Neck Malignancies. Kubicek GJ, Axelrod RS, Machtay M, Ahn PH, Anne PR, Fogh S, Cognetti D, Myers TJ, Curran WJ Jr, Dicker AP. Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):1192-7. Epub 2012 Jan 13.PubMed

Role of Testosterone in Managing Advanced Prostate Cancer. Rove KO, Debruyne FM, Djavan B, Gomella LG, Koul HK, Lucia MS, Petrylak DP, Shore ND, Stone NN, Crawford ED. Urology. 2012 Jul 12.PubMed

Detoxication of Benzo[a]pyrene-7,8-dione by Sulfotransferases (SULTs) in Human Lung Cells. Zhang L, Huang M, Blair IA, Penning TM. J Biol Chem. 2012 Aug 24;287(35):29909-20.PubMed

A Novel Survival-Based Tissue Microarray of Pancreatic Cancer Validates MUC1 and Mesothelin as Biomarkers. Winter JM, Tang LH, Klimstra DS, Brennan MF, Brody JR, Rocha FG, Jia X, Qin LX, D'Angelica MI, Dematteo RP, Fong Y, Jarnagin WR, O'Reilly EM, Allen PJ. PLoS One. 2012;7(7):e40157.PubMed

◊ Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment: Chemoprevention with Rapamycin, an mTOR Inhibitor and Anti-Aging Drug. Mercier I, Camacho J, Titchen K, Gonzales DM, Quann K, Bryant KG, Molchansky A, Milliman JN, Whitaker-Menezes D, Sotgia F, Jasmin JF, Schwarting R, Pestell RG, Blagosklonny MV, Lisanti MP. Am J Pathol. 2012 Jul;181(1):278-93.PubMed

◊ Heat shock protein 90 inhibition: rationale and clinical potential. Den RB, Lu B. Ther Adv Med Oncol. 2012 Jul;4(4):211-8.PubMed

◊ Implanted Dosimeters Identify Radiation Overdoses During IMRT for Prostate Cancer. Den RB, Nowak K, Buzurovic I, Cao J, Harrison AS, Lawrence YR, Dicker AP, Showalter TN. Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):e371-6.PubMed

Molecular profiling of synchronous and metachronous cancers of the pancreas reveal molecular mimicry between samples from the same patient. Talbott VA, Yeo CJ, Brody JR, Witkiewicz AK. J Surg Res. 2012 Jul;176(1):154-8.PubMed

Overexpression of the VSSC-associated CAM, beta-2, enhances LNCaP cell metastasis associated behavior. Jansson KH, Lynch JE, Lepori-Bui N, Czymmek KJ, Duncan RL, Sikes RA. Prostate. 2012 Jul 1;72(10):1080-92. doi: 10.1002/pros.21512.PubMed

Role of SOCS2 in Modulating Heart Damage and Function in a Murine Model of Acute Chagas Disease. Esper L, Roman-Campos D, Lara A, Brant F, Castro LL, Barroso A, Araujo RR, Vieira LQ, Mukherjee S, Gomes ER, Rocha NN, Ramos IP, Lisanti MP, Campos CF, Arantes RM, Guatimosim S, Weiss LM, Cruz JS, Tanowitz HB, Teixeira MM, Machado FS. Am J Pathol. 2012 Jul;181(1):130-40. PubMed

Subharmonic microbubble emissions for noninvasively tracking right ventricular pressures. Dave JK, Halldorsdottir VG, Eisenbrey JR, Raichlen JS, Liu JB, McDonald ME, Dickie K, Wang S, Leung C, Forsberg F. Am J Physiol Heart Circ Physiol. 2012 Jul;303(1):H126-32.PubMed

◊ Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Salem AF, Whitaker-Menezes D, Lin Z, Tanowitz HB, Al-Zoubi MS, Howell A, Pestell RG, Sotgia F, Lisanti MP. Cell Cycle. 2012 Jul 1;11(13):2545-56.PubMed

◊ Value of contrast-enhanced ultrasonography in prostate cancer. Kundavaram CR, Halpern EJ, Trabulsi EJ. Curr Opin Urol. 2012 Jul;22(4):303-9.PubMed

◊ Proline-Rich Tyrosine Kinase 2 (Pyk2) Regulates IGF-I-Induced Cell Motility and Invasion of Urothelial Carcinoma Cells. Genua M, Xu SQ, Buraschi S, Peiper SC, Gomella LG, Belfiore A, Iozzo RV, Morrione A. PLoS One. 2012;7(6):e40148.PubMed

June

The Use of Multiple Time Point Dynamic Positron Emission Tomography/Computed Tomography in Patients With Oral/Head and Neck Cancer Does Not Predictably Identify Metastatic Cervical Lymph Nodes. Carlson ER, Schaefferkoetter J, Townsend D, McCoy JM, Campbell PD Jr, Long M. J Oral Maxillofac Surg. 2012 Jun 26.PubMed

Efficient Bayesian joint models for group randomized trials with multiple observation times and multiple outcomes. Xu X, Pennell ML, Lu B, Murray DM. Stat Med. 2012 Jun 25. doi: 10.1002/sim.5414.PubMed

The RacGAP β2-Chimaerin Selectively Mediates Axonal Pruning in the Hippocampus. Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL. Cell. 2012 Jun 22;149(7):1594-606.PubMed

Diagnostic, prognostic, and predictive biomarkers in pancreatic cancer. Winter JM, Yeo CJ, Brody JR. J Surg Oncol. 2012 Jun 21. doi: 10.1002/jso.23192.PubMed

◊ Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Capparelli C, Guido C, Whitaker-Menezes D, Bonuccelli G, Balliet R, Pestell TG, Goldberg AF, Pestell RG, Howell A, Sneddon S, Birbe R, Tsirigos A, Martinez-Outschoorn U, Sotgia F, Lisanti MP. Cell Cycle. 2012 Jun 15;11(12):2285-302.PubMed

Chk2 Phosphorylation of Survivin-ΔEx3 Contributes to a DNA Damage-Sensing Checkpoint in Cancer. Lopergolo A, Tavecchio M, Lisanti S, Ghosh JC, Dohi T, Faversani A, Vaira V, Bosari S, Tanigawa N, Delia D, Kossenkov AV, Showe LC, Altieri DC. Cancer Res. 2012 Jun 15.PubMed

◊ CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Capparelli C, Whitaker-Menezes D, Guido C, Balliet R, Pestell TG, Howell A, Sneddon S, Pestell RG, Martinez-Outschoorn U, Lisanti MP, Sotgia F. Cell Cycle. 2012 Jun 15;11(12):2272-84.PubMed

Evidence for Efficacy of New Hsp90 Inhibitors Revealed by Ex Vivo Culture of Human Prostate Tumors. Centenera MM, Gillis JL, Hanson AR, Jindal S, Taylor RA, Risbridger GP, Sutherland PD, Scher HI, Raj GV, Knudsen KE, Yeadon T; for the Australian Prostate Cancer BioResource, Tilley WD, Butler LM. Clin Cancer Res. 2012 Jun 15.PubMed

◊ Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis. Li W, Tai Y, Zhou J, Gu W, Bai Z, Zhou T, Zhong Z, McCue PA, Sang N, Ji JY, Kong B, Jiang J, Wang C. Cell Cycle. 2012 Jun 15;11(12):2348-58.PubMed

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Induces Death Receptor 5 Networks That Are Highly Organized. Valley CC, Lewis AK, Mudaliar DJ, Perlmutter JD, Braun AR, Karim CB, Thomas DD, Brody JR, Sachs JN. J Biol Chem. 2012 Jun 15;287(25):21265-78.PubMed

Association Between Pulmonary Mycobacterium Avium Complex Infection and Lung Cancer. Lande L, Peterson DD, Gogoi R, Daum G, Stampler K, Kwait R, Yankowski C, Hauler K, Danley J, Sawicki K, Sawicki J. J Thorac Oncol. 2012 Jun 13.PubMed

Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. Zhao X, Feng D, Wang Q, Abdulla A, Xie XJ, Zhou J, Sun Y, Yang ES, Liu LP, Vaitheesvaran B, Bridges L, Kurland IJ, Strich R, Ni JQ, Wang C, Ericsson J, Pessin JE, Ji JY, Yang F. J Clin Invest. 2012 Jun 11. pii: 61462. doi: 10.1172/JCI61462.PubMed

◊ A Phase I Study of the Combination of Sorafenib With Temozolomide and Radiation Therapy for the Treatment of Primary and Recurrent High-Grade Gliomas. Den RB, Kamrava M, Sheng Z, Werner-Wasik M, Dougherty E, Marinucchi M, Lawrence YR, Hegarty S, Hyslop T, Andrews DW, Glass J, Friedman DP, Green MR, Camphausen K, Dicker AP. Int J Radiat Oncol Biol Phys. 2012 Jun 9.PubMed

A control engineering approach to understanding the TGF-β paradox in cancer. Chung SW, Cooper CR, Farach-Carson MC, Ogunnaike BA. J R Soc Interface. 2012 Jun 7;9(71):1389-97.PubMed

A bodyweight-dependent allometric exponent for scaling clearance across the human life-span. Wang C, Peeters MY, Allegaert K, van Oud-Alblas HJ, Krekels EH, Tibboel D, Danhof M, Knibbe CA. Pharm Res. 2012 Jun;29(6):1570-81.PubMed

A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability. Xiao H, Yu Z, Wu Y, Nan J, Merry DE, Sekiguchi JM, Ferguson DO, Lieberman AP, Dressler GR. Hum Mol Genet. 2012 Jul 6.PubMed

Atherosclerosis, caveolae and caveolin-1. Pavlides S, Gutierrez-Pajares JL, Danilo C, Lisanti MP, Frank PG. Adv Exp Med Biol. 2012;729:127-44. Review.PubMed

Can anyone spare a little indigo carmine? The drug shortage crisis. Gomella LG. Can J Urol. 2012 Jun;19(3):6238.PubMed

◊ Caveolin-1 and breast cancer: a new clinical perspective. Mercier I, Lisanti MP. Adv Exp Med Biol. 2012;729:83-94. Review.PubMed

Characterization of headache after traumatic brain injury. Lucas S, Hoffman JM, Bell KR, Walker W, Dikmen S. Cephalalgia. 2012 Jun;32(8):600-6.PubMed

◊ Hydroxyethyl disulfide as an efficient metabolic assay for cell viability in vitro. Li J, Zhang D, Ward KM, Prendergast GC, Ayene IS. Toxicol In Vitro. 2012 Jun;26(4):603-12.PubMed

Mucinous colloid carcinoma of the colon metastatic to the breast. Yoder MC, Bannon JP, Mitchell EP, Morris GJ. Semin Oncol. 2012 Jun;39(3):e1-7.PubMed

New image processing technique for evaluating breast microcalcifications: a comparative study. Machado P, Eisenbrey JR, Cavanaugh B, Forsberg F. J Ultrasound Med. 2012 Jun;31(6):885-93.PubMed

Recent developments in the interactions between caveolin and pathogens. Machado FS, Rodriguez NE, Adesse D, Garzoni LR, Esper L, Lisanti MP, Burk RD, Albanese C, Van Doorslaer K, Weiss LM, Nagajyothi F, Nosanchuk JD, Wilson ME, Tanowitz HB. Adv Exp Med Biol. 2012;729:65-82. Review.PubMed

◊ Reply letter to: Salvage radiotherapy: A plea for dose-escalation with intensity modulated radiotherapy. Ohri N, Dicker AP, Showalter TN. Eur J Cancer. 2012 Jun;48(9):1414.PubMed

Three-dimensional subharmonic ultrasound imaging in vitro and in vivo. Eisenbrey JR, Sridharan A, Machado P, Zhao H, Halldorsdottir VG, Dave JK, Liu JB, Park S, Dianis S, Wallace K, Thomenius KE, Forsberg F. Acad Radiol. 2012 Jun;19(6):732-9. PubMed

Value of enhanced transrectal ultrasound targeted biopsy for prostate cancer diagnosis: a retrospective data analysis. Aigner F, Schäfer G, Steiner E, Jaschke W, Horninger W, Herrmann TR, Nagele U, Halpern EJ, Frauscher F. World J Urol. 2012 Jun;30(3):341-6.PubMed

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